News

Onchilles Pharma Appoints Christopher Twitty, Ph.D., Chief Scientific Officer

Company also announced the appointments of Ingrid Joseph, DVM, Ph.D., as Senior Vice President, Preclinical Development and Sonia Feau, Ph.D., as Director of Biology SAN DIEGO, October 26, 2021 – Onchilles Pharma announced today the expansion of the company’s scientific team with key leadership appointments. Drs. Christopher Twitty, Ingrid Joseph, and Sonia Feau will be…

News

SDBJ: Onchilles Pharma Raises $7M for Targeted Cancer Therapy

Natallie Rocha of the San Diego Business Journal talked with Onchilles after the announcement of a $7 million Series A financing. “The infusion of funding will bolster Onchilles’ development of a new cancer treatment and finding the Achilles heel of oncology as the biotech’s name suggests,” said Court R. Turner, co-founder and executive chair of…

News

BioWorld: Onchilles looks for cancer’s Achilles heel with a $7M series A

Lev Becker spent about six years studying how to release neutrophile elastase from human neutrophils so it could select cancer cell types that need killing and ignore non-cancer cells. That research eventually led to a recent publication in Cell and the launch of Onchilles Pharma Inc. To read the full article, click here.

News | Press Releases

Onchilles Pharma Raises $7 Million Series A to Advance Drug Candidates to Activate Newly Discovered Broad-Acting Anticancer Pathway

– Foundational research published today in Cell is the first to describe ELANE, a major anti-cancer protein released by human neutrophils that activates cell death pathways specifically in cancer cells – ELANE demonstrates broad and selective cancer killing efficacy and attenuation of tumor growth and metastases in multiple preclinical models – Financing will advance the…

News

Could neutrophils be the secret to cancer’s Achilles’ heel?

A study published in the June 10, 2021 issue of Cell describes a remarkable new mechanism by which the body’s own immune system can eliminate cancer cells without damaging host cells. The findings have the potential to develop first-in-class medicines that are designed to be selective for cancer cells and non-toxic to normal cells and…

News

Cancer’s Achilles Heel? UChicago Startup Secures $7 Million to Develop Unique Treatment

Onchilles Pharma recently closed its Series A funding round, bringing in approximately $7 million, including a $500,000 investment from the University of Chicago’s Startup Investment Fund. Cofounded by UChicago Associate Professor of Ben May Department of Cancer Research, Lev Becker, and LYZZ Capital Partner, Court Turner, the company is developing first-in-class medicines that are designed…

News

Nature Reviews Drug Discovery: A Protease with Far-Reaching Anti-Cancer Effects

Although cancer therapies are becoming increasingly specific to the tumour and mutation type, a potent tumour-agnostic and mutation-agnostic targeted agent would have a high overall therapeutic utility. Writing in Cell, Cui and colleagues have identified that neutrophil elastase (ELANE), via CD95 (also known as FASL and tumour necrosis factor ligand superfamily member 6) and histone…